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Notably, the Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial, the first dedicated kidney outcome trial evaluating canagliflozin in people with type 2 diabetes mellitus and CKD, demonstrated a substantial reduction in the risk of kidney events [46]

When my cat wouldn't eat I went to the pet store and bought one can of just about everything and offered a bit from each one once every hour until she found one that didn't repulse her

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Central nervous system effects have been reported occasionally, including headaches, dizziness, insomnia, and irritability