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Institutional review board (IRB) approval is essential for human research, with long-term protocols needing very careful ethical review

Periodic monitoring of relevant biomarkers provides some assurance that no harmful accumulation is occurring

No es recomendable su uso en mujeres embarazadas o en periodo de lactancia, puesto que algunos componentes pueden ocasionar posibles efectos secundarios

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279 In Escherichia coli , an elevated ratio of NADH to NAD + inhibits pyruvate dehydrogenase (PDH) activity, impeding the formation of acetyl-CoA, as the conversion of pyruvate to acetyl-CoA relies on PDH