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doi: 10.1016/j.npep.2012.09.002

Supporting Studies 1.Wilding et al

1 , 2 The perianal skin in both genders usually displays some degree of physiologic hyperpigmentation

is inhibited by high extracellular Glu concentration, and decreasing intracellular GSH leads to peroxidase 4 (GPX4) inhibition and lipoxygenase (LOX) activation