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This normal metabolic adaptation means weight loss often becomes slower and steadier after the initial weeks of treatment

And then for the patients that experience, I know some worries from people are, oh, I'm going to have all this loose skin

The body is still adjusting to the medication, and dosages are typically lower during this phase

Genetic variations in GLP-1 and GIP receptor density and sensitivity mean that some people need higher absolute concentrations to maintain the same level of receptor activation

I still have 3 pounds to go

Mean percentage weight loss was around -19.2% Vs -14.0 %, with a mean difference of -5.2 %