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At the beginning of the study, and after 1,2 and 3 months several evaluations were carried out, after which all data were statistically compared

To avoid or minimize these effects, the medications are started at a low dose and then ramped up slowly over a few months

Whilst indistinguishable in many respects, these empty capsids are inherently less stable than an infectious virus and prone to switching conformation from the native D-antigenic state to the less immunogenic C-antigenic structure 12