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GLP-1 Agonists Show Promise in Treating Substance Use Disorders Nov 7, 2025 5 min read Updated: Dec 17, 2025 In recent years, medications originally developed to treat Type 2 diabetes, obesity, and other weight-related conditionssuch as semaglutide and liraglutideare showing promise in treating substance use disorders (SUDs)

However, studies were conducted in Asian populations with significantly darker baseline skin tones (Fitzpatrick IVVI), effects were not permanent, and outcomes were variable one included trial found no significant change