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Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor-Expressing Glutamatergic Neurons
WM, XZ and YT reviewed and revised the manuscript
In the SURMOUNT-1 trial, participants without diabetes lost an average of 15-20% of their body weight over 72 weeks, depending on the dose (5 mg, 10 mg, or 15 mg weekly)
Expanding treatment options gives clinicians greater flexibility to tailor care to individual patient needs and preferences
At the residue level, signaling initiation by either peptide 20, tirzepatide or endogenous peptide hormones rendered a common arrangement of residue contacts for the three receptors, including the reorganization of the central polar network that located just below the peptide binding site, opening of the hydrophobic packing to favor the formation of the TM6 kink at the PXXG motif and the rearrangement of two polar networks (HETX motif and TM2-6-7-helix 8) at the cytoplasmic face 33,34
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