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The medication causes gastrointestinal problems, such as nausea, vomiting, diarrhea, and constipation, in most patients, particularly during the initial stages of treatment

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That said, even with triple the vitamin B12 intake, pregnant mothers serum vitamin B12 dipped into the low-to-mid range of normal in this study

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First-pass metabolism occurs when a large portion of L-arginine gets broken down by the enzyme arginase in your liver and intestines before it can reach your bloodstream