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All the four metabolites are not known to have any in vivopharmacological activity

Constipation and other digestive changes may develop later (around week two to week four) and can last longer than nausea if not actively managed with hydration and fiber

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Immediately discontinue phentermine and topiramate extended-release capsules if symptoms develop

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This refluxing step was repeated twice, followed by centrifugation, and washing with ethanol