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This response encourages fibroblasts within the dermis to become more active, supporting the production of collagen fibers that contribute to skin firmness and structure

Fu LW, Vender RB

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10.1016/j.lfs.2022.120861 20 AtarashiK.TanoueT.ShimaT.ImaokaA.KuwaharaT.MomoseY.et al

Usui, John P

Studies indicate that it provides protective effects on IL-1 (20 ng/mL) and TNF- (20 ng/mL)-stimulated C20A4 human chondrocytes in vitro , at concentrations of 3, 5, and 10 M, with 10 M identified as the optimal dose