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Prior studies have demonstrated that neural circuits such as the BLA-PFC, VTA-BLA, and hippocampus(Hip)-BLA are involved in the regulation of anxiety and depressive states [6,10,19]

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Retatrutide, as a triple agonist (GLP-1R + GIPR + GCGR) , is hypothesised to build on these benchmarks by adding the thermogenic and lipolytic effects attributed to glucagon receptor activation

They were later FDA-approved for weight loss in 2014

doi: 10.3389/fendo.2022.936171 196 LacailleHVacherCMPennAA