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Although animal models provide a more integrated physiological context, their translational value is limited by interspecies differences in copper metabolism and the difficulty in modelling human-specific gene-environment interactions [253]

Conjugated bile salts are more water-soluble and generally less toxic (51), whereas unconjugated forms, such as sodium cholate, tend to be more potent but are more toxic (46)

STK11/LKB1 genomic alterations are associated with inferior clinical outcomes with chemo-immunotherapy in non-squamous NSCLC

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BPC-157's action profile in treating amphetamine addiction involves reducing activation of the dopaminergic system in the striatum, which immediately interferes with amphetamine activity