In a psoriasis-like skin model induced with imiquimod in obese diabetic mice, treatment with liraglutide has been demonstrated to decrease psoriasis clinical scores and downregulate major inflammatory cytokines, which include IL-17, IL-22, IL-23 and TNF- [205]
The GLP-1 and breastfeeding guide covers the nuances of this topic, but the general recommendation is to stop GLP-1 treatment at least 2 months before attempting conception due to the long half-life
These mechanistic findings provide a biological foundation for the CV benefits observed in clinical trials and support further exploration of novel incretinbased therapies across cardiometabolic disorders
As a result, clinicians must consider how gastrointestinal tolerability evolves once patients move beyond the controlled environment of trials
They work best with medical guidance and consistent effort
That is the Anschutz Health & Wellness Center