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Exenatide has been observed to accumulate in the brain parenchyma of rodent models, and lixisenatide has demonstrated relatively rapid CNS penetration, likely due to its smaller size, lack of extensive protein binding, and susceptibility to endocytosis [70]

Treatment options include surgical resection, chemotherapy (often using drugs like doxorubicin and ifosfamide), radiation therapy, and newer targeted therapies, such as MEK inhibitors, which focus on specific genetic mutations in the tumor

Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics

The AlphaFold structure was submitted to the Protein Preparation Workflow on Maestro, by Schrodinger (Suite 2024-4) , to reassign bond orders using CCD (Chemical Component Dictionary) database, add/replace hydrogens, fill in missing side chains, generate disulfide bonds, optimize hydrogen bonds with PROPKA , and perform restrained minimization to 0.30 root mean-square deviation (RMSD) using the OPLS4 force field