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Side effects may increase when combining both medications, including gastrointestinal issues and elevated heart rate or blood pressure

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Even after three cycles of NFT exposure (with 24-h washout phases), no signs of desensitization were observed (data not shown)

In another double blind trial (PIONEER 6) which focused on cardiovascular outcomes, 3,183 patients with diabetes and obesity (mean BMI 32.3) were treated for 16 months