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In these patients, the continuous development of the disease leads to continuous damage to the cartilage and subchondral bone, which in turn exacerbates symptoms such as joint pain, dysfunction, and deformities, seriously affecting daily life
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The latest research has found that dihydroorotate dehydrogenase (DHODH) in mitochondria can regulate ferroptosis through a GSH-independent pathway, which provides a new idea for precise targeted regulation of ferroptosis (38)
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The National Institute for Health and Care Excellence (NICE) recognises semaglutide's role in diabetes management, particularly for patients requiring additional glycaemic control or those who would benefit from weight reduction
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