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When to seek medical advice : Contact your GP or diabetes specialist promptly if you experience: Severe, persistent vomiting or diarrhoea leading to dehydration Severe abdominal pain, particularly if radiating to the back (potential pancreatitis) Signs of hypoglycaemia (if taking insulin or sulphonylureas concurrently) Symptoms of gallbladder problems (pain in the upper right abdomen, fever, yellowing of skin) Any changes in vision (rapid improvement in blood glucose can sometimes worsen diabetic retinopathy) [20] Unexplained persistent nausea beyond the first few weeks If you are planning pregnancy, discuss this with your healthcare provider as GLP-1 RAs are not recommended during pregnancy or breastfeeding
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and this is more likely to happen when administered parenterally in an uncontrolled manner
Increased fat synthesis based on enhanced glycolytic activity (pklr1, sterol regulatory element-binding protein-1 [SREBP1c], fas, and liver X receptor a [lxra]) in aged mice partly accounted for hepatic steatosis (increased leukocytic infiltration) and necrosis (increased plasma aspartate aminotransferase [AST] activity), compared with reduced srebp1c and fas mRNA levels in young mice
