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In animal models, activation of these receptors has been shown to modulate neuronal firing patterns and the KNDy (kisspeptin/neurokinin B/dynorphin) network, thereby influencing GnRH/LH pulsatility and estrous cyclicity (8991)

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Glucuronic acid conjugation, sulfate conjugation, amino acid conjugation, glutathione conjugation, acetylation, methylation are different types of phase II metabolic reactions