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Since the approval of semaglutide as Wegovy and tirzepatide as Zepbound, pharmaceutical companies and investors have been watching closely for the next therapy capable of matching or exceeding their clinical benchmarks

10.1016/j.mcna.2021.01.003 114 TosiniG.FergusonI.TsubotaK

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The interaction between appetite suppression and growth hormone secretion requires careful monitoring

That pattern, symptoms clustering when the dose steps up and easing as the body adjusts, is why both products titrate slowly rather than starting at a full dose