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A meta-analysis published in Obesity Reviews found that weight loss through various interventions (lifestyle changes, bariatric surgery, or pharmacotherapy) was associated with significant increases in total testosterone, with greater weight loss producing larger hormonal improvements (Corona et al., 2013, Obesity Reviews )

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New England Journal of Medicine, Aug 14, 2025

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10.1038/84117 109 TsoukalidouS.KakouM.MavridisI.KoumantouD.CalderoneV.FragaiM.et al (2019)

Involvement of interleukin-6-regulated nitric oxide synthase in hemorrhagic cystitis and impaired bladder contractions in young rats induced by acrolein, a urinary metabolite of cyclophosphamide