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Plasma concentrations decline significantly with age from approximately 200 ng/mL at age 20 to ~80 ng/mL by age 60 making it a compelling target for age-related tissue maintenance and periodontal health

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[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Wald A, Leisenring W, van Burik JA, Bowden RA

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