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Direct epithelial cell damage results in a marked loss of bar- rier function.6 Received:5November2019 | Revised:24March2020 | Accepted:28March202 0 DOI : 10.1111 /nmo.138 58 ORIGINAL ARTICLE Purgative/laxative actions of Globularia alypum aqueous extract on gastrointestinal-physiological function and against loperamide-induced constipation coupled to oxidative stress and inflammation in rats Najla Hajji1 | Dalanda Wannes1 | Mohamed-Amine Jabri1 | Kais Rtibi1 | Haifa Tounsi2 | Afifa Abdellaoui2 | Hichem Sebai1 Abbreviations: Ca2+,calcium;GA AE,Globularia alypum leave s aqueous ext ract