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Under DSHEA, a dietary supplement must contain one or more of the following: It must not be: An approved drug An investigational new drug A biologic A compound investigated as a drug prior to supplement marketing Full reference: Dietary Supplement Health and Education Act (DSHEA)

N Engl J Med 2020;382:211728.ArticlePubMed 39

So far, no Tolerable Upper Intake Level (UL) has been established for B12

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They describe how the blend has been documented in practice, not a prescribed regimen

Treated mice demonstrated retinal cell protection and reduced retinal degeneration, with results comparable to healthy control groups