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PRRT using 177 Lu-octreotate could be a therapeutic option in MTC patients with a high tumor uptake on 111 In-diethylenetriamine pentaacetic acid (DTPA)-octreotide scan and tumor somatostatin receptor type 2a (SSTR2a) receptor expression by immunohistochemistry [48]

This metabolic restructuring is distinct from immune activation and highlights why baseline thyroid function testing and periodic reassessment are essential before and during GLP-1 therapy

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