UniQure said it will submit a marketing application for its Huntingtons disease gene therapy to U.K
The addition of GIP seems to: Improve insulin sensitivity Reduce compensatory metabolic slowdown Enhance fat loss, particularly subcutaneous fat By mimicking the natural actions of GLP-1 and GIP, Tirzepatide helps the body respond more efficiently to insulin, slows digestion, and reduces hungerto support steady, sustainable weight loss
It is unclear whether GIPR agonism enhances weight loss because GIP itself does not affect food intake or energy expenditure, GIPR antagonists induce weight loss in mice and non-human primates (9), and tirzepatide does not cause weight loss in obese Glp1r / mice (10)
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