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The release further states that the patches were independently tested by a U.S

Clinical data showed that participants who skipped titration steps or escalated too quickly experienced nearly double the rate of gastrointestinal adverse events

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Comment: The most common recommendation was that CMS should update the payment rates annually using an inflation index, such as the Consumer Price Index for Urban Consumers (CPI-U) or the Producer Price Index (PPI), rather than recalculating them based on new ASP data