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Taken these findings together, an early postoperative, physiological increase of GLP-2 plasma concentrations in all patients can be observed, regardless of the resected liver volume, indicating an upregulation during liver regeneration, timely persisting in resections of greater extent

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Notably, tirzepatide may reduce the effectiveness of oral contraceptives during dose escalation due to delayed gastric emptying

GLP-1 plays a crucial role in regulating several physiological and metabolic functions, including appetite, satiety, glucose and insulin balance, GI motility, liver fat metabolism, and even bone remodeling (1)

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