Some researchers have proposed that GLP-1 can protect Mller cells from high glucose-induced damage by activating the ERK pathway, which attenuates oxidative stress [74]
Semaglutide was designed from the backbone of another GLP-1R agonist, liraglutide , which has been tested as a prospective neuroprotective treatment option against dementia ( the ELAD study )
Barroso-Sousa R, Barry WT, and Garrido-Castro AC, et al (2018) Incidence of endocrine dysfunction following the use of different immune checkpoint inhibitor regimens: a systematic review and meta-analysis JAMA Oncol 4 (2) 173182 PMCID: 5838579 40
Its active ingredient, tirzepatide, functions as a dual agonist for both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors
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