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doi: 10.3390/BIOMEDICINES9080966 82 YendeSParikhCR

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This glutathione depletion is not merely a consequence of the disease - it is thought to be a contributing driver of disease progression, creating a vicious cycle: oxidative stress depletes glutathione reduced glutathione allows more oxidative damage more protein oxidation stronger autoimmune response more thyroid destruction more oxidative stress

f , Body temperature at indicated time points following transfer of mice from room temperature to cold (6 C) (n = 5 Control and n = 6 NDI1)