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Animal Data Dapagliflozin Dapagliflozin dosed directly to juvenile rats from postnatal day (PND) 21 until PND 90 at doses of 1, 15, or 75 mg/kg/day, increased kidney weights and increased the incidence of renal pelvic and tubular dilatations at all dose levels

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In clinical trials, patients on the maintenance dose lost an average of around 15% of their body weight over 68 weeks alongside a reduced calorie diet and more physical activity