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While some studies in PD models have revealed neuroprotective functions related to dopaminergic neuron survival, others have suggested a proinflammatory effect in LPS-treated models in which IL-4 exacerbates microglial activation and BBB disruption [187, 211]

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As stated in section 1115A(d)(3) of the Act, Chapter 35 of title 44, United States Code, shall not apply to the testing, evaluation, and expansion of models under section 1115A of the Act