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Additionally, external and iatrogenic factors such as radiation and xenobiotics are increasingly recognized as disruptors of gutbrain homeostasis, contributing to neurotoxicity and immune dysregulation

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The toxin typically spreads about a centimetre from where it's injected and this diffusion explains its effectiveness in treating both oil and sweat glands, as well as muscles under the skin

If patients experience intolerable side effects at a given dose, maintaining the current dose for an additional 4 weeks or temporarily reducing the dose may improve tolerance before attempting further escalation