Singh says about half his patients experience these gastrointestinal side effects, especially at first
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The active ingredient, semaglutide, is FDA-approved in branded products (Wegovy, Ozempic), but a compounded preparation is not itself an FDA-approved drug
Importantly, routine thyroid function testing is not required by the label, though Zepbound is contraindicated in patients with personal or family history of medullary thyroid carcinoma or MEN2
Third, the self-controlled case series design accounts for time-invariant confounders like genetic predisposition and personality traits
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