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In STEP 2, the clinical expert consulted by CADTH on this review noted that the inclusion criteria would not be generalizable to patients with type 2 diabetes who are receiving insulin, which could be a significant number of patients
This allows approximately 5 half-lives of drug clearance, reducing fetal exposure risk during early organogenesis when developmental effects are most critical
citri GSTs [25]
Dosing considerations also apply to pregnant or breastfeeding women, pediatric patients, and older adults