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Over time, pharmacological engineering enabled: Short-acting injectables (e.g., exenatide) Long-acting once-weekly injectables (liraglutide, semaglutide) Multi-target incretin therapies (tirzepatide) Oral peptide formulations and now oral small molecules The most recent breakthrough is the development of orally available GLP-1 receptor agonists, including: Orforglipron (Lilly) Elecoglipron (AstraZeneca) These compounds eliminate the need for injection and could dramatically expand accessibility and adherence in obesity and diabetes populations

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Subscript T and R represent the test preparation and the reference preparation for extravascular administration, respectively, while D represents the administered dose

10.1016/S0016-5085(98)70160-X Gastroenterology 44 MariM.CaballeroF.ColellA.MoralesA.CaballeriaJ.FernandezA.et al (2006)