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FIGURE 8 3.5 Establishment and validation of Deg-AZM PBPK models in rats The parameters collected from preclinical studies were used to establish PBPK models of Deg-AZM (listed in Table 7), followed by validation using PK data of rats

The safety profile of GLP-1 injections is well-established, with many individuals experiencing minimal side effects

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The STEP 1 extension study showed that participants who discontinued semaglutide after 68 weeks regained approximately two-thirds of the lost weight within one year

Despite these promising advances, clinical validation remains limited by small cohort sizes, short follow-up durations, and inconsistent trial designs

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