MEG designed the study, applied for approval from the Research Ethics Board, and reviewed the manuscript draft
Chondrocyte dedifferentiation was majorly characterized as the reduced expression of COL2 and ACAN and enhanced expression of type I collagen and versican ( COL2 expression, but not ACAN ( In addition to dedifferentiation, another consequence of in vitro expansion is replicative senescence, which also significantly influences chondrocyte function
Biomarker studies: establishing senescent cell burden diagnostic (e.g., imaging, blood markers) to monitor effect and guide dosing
If you have allergies, kidney stones , or digestive problems, talk to your doctor at Fallbrook Medical Center for help
If taking medication or if you have a medical condition, consult your healthcare professional before use
D.McKinzieS.StamblerN.et al