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Ferroptotic injury promotes the release of pro-inflammatory mediators and amplifies oxidative stress (79), which can aggravate microcirculatory dysfunction and hypoxia, thereby reactivating HIF programs and further perturbing iron handling
10.1016/j.cmet.2019.01.020 Summary Keywords xCT transporter, cysteine, lipid peroxides, glutathione, ferroptosis, tumor-resistance Citation Daher B, Vueti M and Pouyssgur J (2020) Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death
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