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The presence of two variants ( ALDH3A1*2 and ALDH1A1*2 ) is known to reduce the activity of the ALDH enzyme, which affects the detoxification capacity of cyclophosphamide (CYC), theoretically increasing the risk of toxicity from CYC (Ekhart et al., 2008)

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10.1186/s40168-021-01126-6 Summary Keywords butyrate, diabetes, GLP-1, gut microbiota, leonurine, MPC2 Citation Zhang Y, Chen W, Yu X, Feng J, Sammad A, Wang Z and Yin K (2026) Leonurine ameliorates experimental type 2 diabetes through gut microbiota remodeling, enhanced butyrate production, and MPC2 activation to restore GLP-1 secretion

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Fortunately, fixed-ratio combination drugs appear to reduce nausea rates by about 50%