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15,20 Although many of these AEs have occurred early in therapy and subsided over time, they remain a primary reason for dose adjustment or discontinuation
In the United States, prescribing information for all medications licensed for obesity that act on the CNS, including the GLP-1RAs liraglutide 3 mg (Saxenda) and semaglutide 2.4 mg (Wegovy), must include the recommendation of monitoring for depression and suicidal ideation 231
The higher dose generic orlistat (120mg) is available on the NHS if you meet specific requirements, such as a body mass index of 30 or more or a BMI of 28 or more with weight-related health conditions, like high blood pressure or type 2 diabetes
Blood pressure effects have been favorable, with dose-dependent reductions in systolic blood pressure of 3.5-5.6 mmHg in the ATTAIN-1 trial, likely related to weight loss, reduced sodium intake, and direct vascular GLP-1 receptor effects
2013;8(7):e69010
Its goal is to enable sustainable weight loss and help users make long-term lifestyle changes
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