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This higher threshold is largely due to larger kidneys and livers relative to body size in children versus adults, and hence greater tolerance of paracetamol overdose than adults.[35] Acute paracetamol overdose in children rarely causes illness or death with chronic, supratherapeutic doses being the major cause of toxicity in children

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Given GLP-1R as the therapeutic target, a structural basis of the GLP-1-GLP-1R interaction is paramount for the design of GLP-1 analogues that fully harness the therapeutic potential of GLP-1R activation