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Focus areas: Increase protein target to 1.4 to 1.6 grams per kilogram Consider adding a calorie-dense protein shake (protein powder blended with nut butter, banana, olive oil) to ensure minimum caloric intake Increase resistance training to three sessions weekly if tolerated Add magnesium glycinate 200 to 400 mg at bedtime if not already supplementing Monitor body composition if possible, not just scale weight At this dose, the people who struggle most are those who have not established the nutritional and exercise foundations recommended at lower doses

Recent research findings highlight the broader therapeutic applications of GLP-1 agonists, including their cardiovascular, neuroprotective, and anti-inflammatory benefits

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A meta-analysis of randomized clinical trials evaluating the use of GLP-1 receptor agonists and the occurrence of bone fractures in patients with T2DM observed that these medications did not reduce the incidence of fractures compared with other antidiabetic medications [62]