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Research indicates that facial flushing and stretching complex long term responses may occur in experimental subjects

Most GI side effects peak between weeks four and eight and resolve by week twelve for the majority of users

Fabbrini E, Magkos F, Mohammed BS, Pietka T, Abumrad NA, Patterson BW, Okunade A, Klein S (2009) Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity