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These phenotypic differences lie in single amino acid changes that greatly affect the structure and therefore binding affinity of ApoE, with ApoE3 containing Cys-112 and Arg-158, ApoE2 having Cys-112 and Cys-158, and finally ApoE4 with Arg-112 and Arg-158 (Huang and Mahley, 2014)

AHK-Cu (Alanyl-Histidyl-Lysine-Copper) was the focus of this study and showed strong follicle-stimulating and anti-apoptotic effects

VGF is a member of the granin family, and the coordination among its family members plays a crucial role in the biogenesis of secretory granules 22

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In contrast, AMS-NE-ISG displayed an improved sustained-release profile (~100% at 8 h)