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In current clinical practice, the GLP-1 receptor agonists with approved indications for the treatment of pediatric obesity are liraglutide and semaglutide

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While the peptide demonstrates GH-releasing properties in published studies, the body of human clinical evidence specifically for longevity or performance applications remains more limited compared to some other secretagogues

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RNA sequencing of intestinal enterocytes pre- and post-roux-en-Y gastric bypass reveals alteration in gene expression related to enterocyte differentiation, restitution, and obesity with regulation by Schlafen 12