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The elevated levels of COX-2 are one more marker associated with the arbitration and progression of thermal hyperalgesia and mechanical allodynia ( via p -NF-B prompts changes to the osmolyte levels in nerves and augmented vasoconstrictors, together with thromboxane accumulation ( + - K + activity and augment the production of vasoconstrictor thromboxane ( p - NF-B pathway and elevated levels of proteins consisting of TNF- and COX-2

[DOI] [PubMed] [Google Scholar] [58].Upchurch GR Jr., Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF Jr., Loscalzo J, Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase

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