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Systematic data describing how this feedback loop evolves across DR stages (non-proliferative versus proliferative) are also lacking, making it difficult to align potential interventions with the precise windows of the clinical disease course

The GLP-1 agonist handles post-meal glucose spikes and provides appetite suppression that counteracts insulin-related weight gain

It also decreases acid secretion and stomach motility, as well as allows for decrease in grehlin and increase in leptin, which collectively decreases appetite

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