However, it did improve anxiety symptoms in the patients.[ref] A meta-analysis of clinical trials using 900 2700 mg/day showed that NAC may improve hearing loss (noise-induced).[ref] Keep in mind that these studies involved patients who were likely to have increased glutathione use
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[DOI] [PMC free article] [PubMed] [Google Scholar] [55].Kietadisorn R, Juni RP, Moens AL, Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities
Research has also demonstrated that metformin increases the abundance of Akkermansia muciniphila in the gut, which triggers the transcription of host antioxidant genes, including Nqo1 , Ho-1 , and Gpx4 [17]
Endogenous glutathione is known to be important for fungal development, and changes in the intracellular glutathione concentration or ratio can trigger processes such as germination, conidiation and dimorphic transition (3-5)
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