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In head-to-head clinical trials, the overall GI adverse event rates are broadly similar between semaglutide 2.4mg and tirzepatide at its maximum dose

First, confirm it is a true plateau, at least three weeks of no downward trend in the weekly average, rather than normal fluctuation

SGLT2 inhibitors attenuate oxidative stress through multifaceted mechanisms encompassing glucotoxicity reduction and mitochondrial functional enhancement (308)

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Comparing these two trials, after 40 weeks, participants on semaglutide lost an average of 6.9 kg, whereas those on tirzepatide lost 7.8, 10.3, or 12.4 kg, respectively