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The lack of a significant correlation between purine metabolites and 5-HIAA, suggests alterations in key 5-HT pathways that may both be modified by and contribute to oxidative stress via purine catabolism in FENNS

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Mazdeh MA-O, Abolfathi P, Sabetghadam M, Mohammadi YA-O, Mehrpooya MA-O

Notably, two studies controlled the dosage of GLP-1R agonists at a level that would not affect the blood glucose of in vivo DM models, and these two studies demonstrated that the neuroprotective effects of GLP-1R agonists are independent of their blood glucose-lowering effects